4-Bromo-2-methylphenol → 4'-Hydroxy-3'-methyl-[1,1'-biphenyl]-4-carbonitrile

HRID 1167861

반응식

HRID 1167861 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)#[N:2].Br[C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([CH3:20])[CH:14]=1>>[OH:19][C:16]1[CH:17]=[CH:18][C:13]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)=[CH:14][C:15]=1[CH3:20]

참가 물질

3

반응물 2

HCID 168964-Bromo-2-methylphenolHCID 27343264-Cyanophenylboronic acid

생성물 1

HCID 222744974'-Hydroxy-3'-methyl-[1,1'-biphenyl]-4-carbonitrile수율 50%

실험 절차

4-Cyanophenylboronic acid and 4-bromo-2-methylphenol were processed as described in Example 167A to provide the title compound (50% yield). 1HNMR (300 MHz, CDCl3) δ2.40 (s, 3H), 4.85 (bs, 1H), 6.83-7.65 (m, 7H); MS (CDI) m/z 210 (M+H)+.

출처 및 근거

ORD 기록
ord-a21e063f503d43fea0013cda59fe3169
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620839B2

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