Acetyl chloride → HCID 12970146, 화합물

HRID 1167891노트

반응식

HRID 1167891 반응식
[N+:1]([CH2:4][C:5]1([CH2:11][CH2:12][NH2:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)([O-:3])=[O:2].[C:14](Cl)(=[O:16])[CH3:15].C(N(CC)CC)C>O1CCCC1>[N+:1]([CH2:4][C:5]1([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 12970145HCID 12970145, 화합물2회

생성물 1

HCID 12970146HCID 12970146, 화합물수율 69%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The amine hydrochloride salt (compound 4, 0.50 g, 2.25 mmol) was reacted with acetyl chloride (0.20 g, 2.55 mmol) and triethylamine (0.45 g, 4.45 mmol) in tetrahydrofuran following the procedure described in Example 1, Step 4. Purification by chromatography on silica eluting with ethyl acetate gave the required product as a crystalline solid (0.35 g, 69%); mp 68-70° C.

후처리

  1. customPurification by chromatography on silica eluting with ethyl acetate

출처 및 근거

ORD 기록
ord-f78687b871ff4feaaa20482a61d4d847
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620829B2

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