Water → N-(4-bromo-2-methylphenyl)butanamide
반응식
[C:1]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Br:14]Br.O>C(O)(=O)C>[Br:14][C:10]1[CH:11]=[CH:12][C:7]([NH:6][C:1](=[O:5])[CH2:2][CH2:3][CH3:4])=[C:8]([CH3:13])[CH:9]=1참가 물질
5
실험 절차
30 g of N-butyryl-o-toluidine and 150 g of glacial acetic acid were initially charged at 30° C. A solution of 33 g of bromine in 66 g of glacial acetic acid was added with stirring and then stirring was continued at from 25 to 30° C. for 1 hour. 300 ml of water were then added to the reaction mixture which, after continued stirring for a short time, was filtered, the crystals were washed with water and dried under reduced pressure. 42.5 g (98% yield) of N-(4-bromo-2-methylphenyl)butanamide were obtained in 99.4% purity.
후처리
- stirringstirring
- stirringafter continued stirring for a short time
- filtrationwas filtered
- washthe crystals were washed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-cb27b065bf404f3fb13abd026073b5c2
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06620962B2
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