Dichloromethane → 5-Amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylic acid

HRID 1168260노트

반응식

HRID 1168260 반응식
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[C:5]([C:14]([O:16]C)=[O:15])=[CH:4][C:3]=1[Cl:18].C(Cl)Cl>CO>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH:11]([CH3:13])[CH3:12])[N:10]=[C:6]2[C:5]([C:14]([OH:16])=[O:15])=[CH:4][C:3]=1[Cl:18]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 22992220Methyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylate

생성물 1

HCID 229922215-Amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared according to the procedure described in the step 4 in EXAMPLE 1 (METHOD A) from methyl 5-amino-6-chloro-2-isopropylimidazo[1,2-a]pyridine-8-carboxylate (EXAMPLE 20, Step 1). Rf value: 0.33 (CH2Cl2:MeOH, 20:1, v/v)

출처 및 근거

ORD 기록
ord-fb7b5c92304f4f478891f1b243f7a34e
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06624162B2

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