Sodium Iodide → Methyl 5-amino-6-chloro-2-phenylimidazo[1,2-a]pyridine-8-carboxylate

HRID 1168261노트

반응식

HRID 1168261 반응식
[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]([Cl:12])=[C:4]([NH2:13])[N:3]=1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=O.[I-].[Na+]>>[NH2:13][C:4]1[N:3]2[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:1]=[C:2]2[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[Cl:12]

참가 물질

4

반응물 3

HCID 5238Sodium IodideHCID 6259Phenacyl bromideHCID 12088100Methyl 2,6-Diamino-5-chloronicotinate

생성물 1

HCID 22992224Methyl 5-amino-6-chloro-2-phenylimidazo[1,2-a]pyridine-8-carboxylate

실험 절차

The title compounds were prepared according to the procedure described in the step 2 in EXAMPLE 1 (METHOD B) using methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (EXAMPLE 1, METHOD B, Step 1), 2-bromoacetophenone and sodium iodide.

출처 및 근거

ORD 기록
ord-f0774e76eff3468db6465d77bf9f8e14
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06624162B2

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