Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate → 2-{3-[2-(3-Trifluoromethylphenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyloxymethyl}-6-methylbenzoic Acid

HRID 1168446

반응식

HRID 1168446 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=2[C:12]([O:14]C)=[O:13])[CH2:3]1.[F:21][C:22]([F:38])([F:37])[C:23]1[CH:24]=[C:25]([C:29]2[O:30][C:31]([CH3:36])=[C:32]([CH2:34]I)[N:33]=2)[CH:26]=[CH:27][CH:28]=1>>[F:38][C:22]([F:21])([F:37])[C:23]1[CH:24]=[C:25]([C:29]2[O:30][C:31]([CH3:36])=[C:32]([CH2:34][O:1][CH:2]3[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]4[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=4[C:12]([OH:14])=[O:13])[CH2:3]3)[N:33]=2)[CH:26]=[CH:27][CH:28]=1

참가 물질

3

반응물 2

HCID 21980299Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoateHCID 224936812-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

생성물 1

HCID 224936852-{3-[2-(3-Trifluoromethylphenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyloxymethyl}-6-methylbenzoic Acid

실험 절차

Using methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate and 2-(3-trifluoromethylphenyl)4-iodomethyl-5-methyloxazole as starting materials in the procedure of Example XXXI, gave the product 54 of molecular weight 503.52 (C27H28F3NO5), MS(ESI): 504.37 (M+H+).

출처 및 근거

ORD 기록
ord-b5bd3b8bc47b430faba8c9fe0de984be
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06624185B2

연결된 노트

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