Br[CH2:2][C:3](OC(=O)CBr)=[O:4].[CH2:10]([NH:17][CH2:18][C:19]1[CH:20]=[C:21]([CH2:41][N:42]2[CH2:47][CH2:46][O:45][CH2:44][CH2:43]2)[CH:22]=[C:23]2[C:28]=1[N:27]=[CH:26][C:25]([C:29]([NH:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=1)=[O:30])=[C:24]2[OH:40])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C>CN1C(=O)CCC1.O>[CH2:10]([N:17]1[CH2:18][C:19]2=[C:28]3[C:23](=[CH:22][C:21]([CH2:41][N:42]4[CH2:43][CH2:44][O:45][CH2:46][CH2:47]4)=[CH:20]2)[C:24](=[O:40])[C:25]([C:29]([NH:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)=[O:30])=[CH:26][N:27]3[CH2:2][C:3]1=[O:4])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1Bromoacetic anhydride (40 mg) is added to a stirred solution of 8-((benzylamino)methyl)-N-(4-chlorobenzyl)-4-hydroxy-6-(4-morpholinylmethyl)-3-quinolinecarboxamide (Preparation 29, 53 mg) in NMP (0.3 mL). After 30 min, triethylamine (50 mg) is added. The solution is diluted with water and the resulting precipitate is filtered and dried under vacuum to give 44 mg of the title compound. Physical characteristics: HRMS m/z 571.2104 (C32H31ClN4O4).
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