Nitric Acid → 7-Chloro-9-nitro-beta-carboline
반응식
[Cl:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.O.[N+:16]([O-])([OH:18])=[O:17]>>[Cl:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[N:12]2[N+:16]([O-:18])=[O:17])=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of the product from example 12 (500 mg, 2.48 mmol) in concentrated nitric acid (20 ml) was stirred at RT for 22 h. The reaction mixture was carefully poured into cold (3° C. to 5° C.) water (50 ml), and after stirring for 2 h the precipitate was collected. The solid was suspended in saturated aqueous NaHCO3 (50 ml) and stirred at RT for 12 h. The product was filtered and washed with water to provide 550 mg of 7-chloro-9-nitro-β-carboline
후처리
- stirringafter stirring for 2 h the precipitate
- customwas collected
- stirringstirred at RT for 12 h
- filtrationThe product was filtered
- washwashed with water
출처 및 근거
- ORD 기록
- ord-9d933f5a560a449a87dfdd45c7db506f
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06627637B2
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