Potassium Carbonate → HCID 21362788, 화합물

HRID 1168868노트

반응식

HRID 1168868 반응식
[CH:1]([NH:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH2:13][N:14]([CH2:32][CH3:33])[CH:15]2[CH2:24][CH2:23][C:22]3[C:17](=[CH:18][C:19]([NH:25]C(=O)C(F)(F)F)=[CH:20][CH:21]=3)[CH2:16]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:1]([NH:4][C:5]([N:7]1[CH2:8][CH2:9][CH:10]([CH2:13][N:14]([CH:15]2[CH2:24][CH2:23][C:22]3[C:17](=[CH:18][C:19]([NH2:25])=[CH:20][CH:21]=3)[CH2:16]2)[CH2:32][CH3:33])[CH2:11][CH2:12]1)=[O:6])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 86589089HCID 86589089, 화합물

생성물 1

HCID 21362788HCID 21362788, 화합물수율 95.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of the 4-({ethyl-[7-(2,2,2-trifluoro-acetylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amino}-methyl)-piperidine-1-carboxylic acid isopropylamide (630 mg, 1.3 mmol) in methanol (20 mL) and water (10 mL) was added potassium carbonate (500 mg) and the reaction was allowed to stir at room temperature for 24 h. The reaction was concentrated in vacuo and partitioned between EtOAc and water. The organic layer was washed with brine, dried (MgSO4) and concentrated to afford 4-{[(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-ethyl-amino]-methyl}-piperidine-1-carboxylic acid isopropylamide as a light brown oil (464 mg).

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. custompartitioned between EtOAc and water
  3. washThe organic layer was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b764d320b0904505a145c249c3188a9c
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627644B2

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