3-Hydroxy-2-hydroxymethyl-6-methylpyridine → 3-Hydroxy-6-methylpyridine-2-carbaldehyde

HRID 11693

반응식

HRID 11693 반응식
[OH:1][CH2:2][C:3]1[C:8]([OH:9])=[CH:7][CH:6]=[C:5]([CH3:10])[N:4]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][C:5]([CH3:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 1351283-Hydroxy-2-hydroxymethyl-6-methylpyridine

생성물 1

HCID 124219863-Hydroxy-6-methylpyridine-2-carbaldehyde수율 7.1%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-hydroxymethyl-6-methyl-pyridin-3-ol (1.0 g, 7.19 mmol) in methylene chloride (30 mL) at ambient temperature was added manganese dioxide (12.5 g, 143 mmol). The reactions was stirred for 48 hours, then filtered through celite and concentrated to give the title compound (0.070 g).

후처리

  1. filtrationfiltered through celite and
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-02ad876e63fb458292e9317dfd5c8fb7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098212B2

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