4-Hydroxybenzyl Alcohol → 4-(2-Propoxyethoxy)benzyl alcohol

HRID 1169458노트

반응식

HRID 1169458 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.[CH2:10]([O:13][CH2:14][CH2:15]Br)[CH2:11][CH3:12].[I-].[Na+].C(=O)([O-])[O-].[K+].[K+]>O.CN(C=O)C>[CH2:10]([O:13][CH2:14][CH2:15][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1)[CH2:11][CH3:12]

참가 물질

7

반응물 4

HCID 1254-Hydroxybenzyl AlcoholHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 27341841-(2-Bromoethoxy)propane

생성물 1

HCID 27341874-(2-Propoxyethoxy)benzyl alcohol

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A mixture of 4-hydroxybenzyl alcohol (3.00 g), 2-bromoethyl propyl ether (4.0 ml), sodium iodide (4.75 g), potassium carbonate (6.68 g) and DMF (30 ml) was stirred at 90° C. for 3 days. The reaction mixture was mixed with water, and was extracted with ethyl acetate. The organic layer was washed with water and an aqueous saturated solution of sodium chloride, and was dried with magnesium sulfate. After concentration under reduced pressure, the residue was subjected to separation and purification using column chromatography (ethyl acetate:hexane 1:2→1:1) to obtain 4-(2-propoxyethoxy)benzyl alcohol (2.27 g) as a light yellow, oily substance.

후처리

  1. extractionwas extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialan aqueous saturated solution of sodium chloride, and was dried with magnesium sulfate
  4. concentrationAfter concentration under reduced pressure
  5. customthe residue was subjected to separation and purification

출처 및 근거

ORD 기록
ord-9ccbf93b04344f908d4209d823e4aeea
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

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