Thionyl Chloride → 4-Chloromethyl-1,2-diethoxy-benzene

HRID 1169504

반응식

HRID 1169504 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7]O)[CH3:2].S(Cl)([Cl:17])=O>C1(C)C=CC=CC=1.N1C=CC=CC=1.C(OCC)(=O)C>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7][Cl:17])[CH3:2]

참가 물질

6

반응물 2

HCID 24386Thionyl ChlorideHCID 8540533,4-Diethoxybenzyl alcohol

생성물 1

HCID 24348314-Chloromethyl-1,2-diethoxy-benzene

시약·촉매·용매 3

HCID 1049Pyridine촉매HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

실험 절차

To 3,4-diethoxybenzyl alcohol (736 mg) dissolved in toluene (10 ml) were added pyridine (one drop) and thionyl chloride (0.41 ml), and the resulting mixture was stirred at room temperature for 20 minutes. The reaction mixture was diluted with ethyl acetate and the resulting mixture was washed with water, an aqueous saturated solution of sodium hydrogen carbonate and an aqueous saturated solution of sodium chloride, and was dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 3,4-diethoxybenzyl chloride (802 mg) as an oil.

후처리

  1. washthe resulting mixture was washed with water
  2. dry with materialan aqueous saturated solution of sodium hydrogen carbonate and an aqueous saturated solution of sodium chloride, and was dried with anhydrous magnesium sulfate
  3. customThe resulting organic layer was evaporated under reduced pressure
  4. customto remove the solvent

출처 및 근거

ORD 기록
ord-77130ba029794686932449271b456b3a
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

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