Epothilone A → Epothilone C

HRID 1169518

반응식

HRID 1169518 반응식
[Mg].[CH3:2][C:3]1[S:7][CH:6]=[C:5](/[CH:8]=[C:9](/[C@H:11]2[O:29][C:27](=[O:28])[CH2:26][C@H:25]([OH:30])[C:24]([CH3:32])([CH3:31])[C:22](=[O:23])[C@H:21]([CH3:33])[C@@H:20]([OH:34])[C@@H:19]([CH3:35])[CH2:18][CH2:17][CH2:16][C@H:14]3O[C@H:13]3[CH2:12]2)\[CH3:10])[N:4]=1>[Cl-].[Cl-].C1([Ti+2]C2C=CC=C2)C=CC=C1.C1COCC1>[CH3:2][C:3]1[S:7][CH:6]=[C:5](/[CH:8]=[C:9](/[C@H:11]2[O:29][C:27](=[O:28])[CH2:26][C@H:25]([OH:30])[C:24]([CH3:32])([CH3:31])[C:22](=[O:23])[C@H:21]([CH3:33])[C@@H:20]([OH:34])[C@@H:19]([CH3:35])[CH2:18][CH2:17][CH2:16][CH:14]=[CH:13][CH2:12]2)\[CH3:10])[N:4]=1

참가 물질

5

반응물 2

HCID 448799Epothilone AHCID 5462224Magnesium

생성물 1

HCID 9891226Epothilone C수율 80%

시약·촉매·용매 2

HCID 178420582HCID 178420582, 화합물촉매HCID 8028Tetrahydrofuran용매

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온도
-78 °C

실험 절차

To a two-necked flask was added chopped pieces of magnesium turnings (24 mg, 1.0 mmol). The flask was flame-dried under vacuum and cooled under argon. Bis (cyclopentadienyl)titanium dichloride (250 mg, 1.0 mmol) was added followed by anhydrous THF (5 mL). The stirring suspension was evacuated with low vacuum, and the reaction flask was refilled with argon. The red suspension became dark, turning a homogeneous deep green after 1.5 h with nearly all the magnesium metal being consumed. An aliquot (3.5 mL, 0.70 mmol, 3.5 eq) was removed and cooled to −78° C. under argon. To this solution was added epothilone A (99 mg, 0.20 mmol, 1.0 eq). The reaction mixture was warmed to room temperature and stirred for 15 min. The volatiles were removed in vacuo and the residue was chromatographed two times on silica (25 g), eluting with 35% EtOAc/hexanes to give 76 mg (80%) of epothilone C as a pale yellow viscous oil.

후처리

  1. additionTo a two-necked flask was added
  2. customThe flask was flame-dried under vacuum
  3. temperaturecooled under argon
  4. customThe stirring suspension was evacuated with low vacuum
  5. additionthe reaction flask was refilled with argon
  6. customhomogeneous deep green after 1.5 h
  7. custombeing consumed
  8. customAn aliquot (3.5 mL, 0.70 mmol, 3.5 eq) was removed
  9. temperatureThe reaction mixture was warmed to room temperature
  10. customThe volatiles were removed in vacuo
  11. customthe residue was chromatographed two times on silica (25 g)
  12. washeluting with 35% EtOAc/hexanes

출처 및 근거

ORD 기록
ord-5b318823187a4a7daa07ed9c8e714282
출처 데이터셋
uspto-grants-2010_11
특허 번호
USRE041911E1

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