Triethylamine → 4-(Chloromethyl)-6-methoxy-quinoline
반응식
C(N(CC)CC)C.CS([Cl:12])(=O)=O.O[CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1>ClCCl>[Cl:12][CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1참가 물질
5
실험 절차
1.16 ml of triethylamine and 0.64 ml of methanesulfonyl chloride are successively added to a solution of 1.2 g of 4-hydroxymethyl-6-methoxyquinoline in 45 ml of dichloromethane, under an inert atmosphere of argon at a temperature in the region of 20° C. Stirring is maintained at this temperature for 3 hours. The reaction medium is concentrated under reduced pressure to give a brown residue. The product is used without further purification in the following step.
후처리
- temperatureis maintained at this temperature for 3 hours
- concentrationThe reaction medium is concentrated under reduced pressure
- customto give a brown residue
- customThe product is used without further purification in the following step
출처 및 근거
- ORD 기록
- ord-ced5b089534a40448ec45cadf4477ff0
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07825115B2
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