[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Br:9])=[CH:4][N:3]=1.C([O-])([O-])=O.[Cs+].[Cs+].[C:16]([O:20][C:21](=[O:25])[CH2:22][CH2:23][OH:24])([CH3:19])([CH3:18])[CH3:17]>CN(C=O)C.[Cl-].[Na+].O>[C:16]([O:20][C:21](=[O:25])[CH2:22][CH2:23][O:24][C:6]1[C:5]([Br:9])=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=1)([CH3:19])([CH3:18])[CH3:17]2,4-Dichloro-5-bromopyrimidine (7.98 g, 35 mmol) is dissolved in DMF (35 ml) and Cs2CO3 (11.4 g, 35 mmol) and 3-hydroxy-propionic acid tert-butyl-ester (5.12 g, 35 mmol) are added. The reaction mixture is stirred for 5 h at rt. The reaction mixture is diluted with brine and the extracted with ethyl acetate (3×). The organic layers are washed with brine, dried over sodiumsulfat and evaporated to dryness. The crude product is used for the following reaction without any further purification.
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