Methanesulfonyl chloride → N-(1-Phenylethyl)methanesulfonamide

반응식

[CH3:1][S:2](Cl)(=[O:4])=[O:3].[C:6]1([C@@H:12]([NH2:14])[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[C:6]1([CH:12]([NH:14][S:2]([CH3:1])(=[O:4])=[O:3])[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 758181-Phenethylamine, (-)-

생성물 1

HCID 380740N-(1-Phenylethyl)methanesulfonamide

실험 절차

TEA (2.90 mL, 20.9 mmol) and methanesulfonylchloride (2.0 g, 17.46 mmol). were added to a solution of (S)-1-phenyl-ethylamine Compound 3h1 (2.13 g, 17.46 mmol) at 0° C., under a N2 atmosphere. The mixture was stirred for 3 hrs, while warming to r.t. The reaction was quenched with water (20 mL) and the organic layer was diluted with CH2Cl2 (100 mL), washed with water and brine, separated and dried with anhydrous sodium sulfate, then filtered and concentrated in vacuo to yield N-(1-phenyl-ethyl)-methanesulfonamide Compound 3h2 as an oil.

후처리

customThe reaction was quenched with water (20 mL)
additionthe organic layer was diluted with CH2Cl2 (100 mL)
washwashed with water and brine
customseparated
dry with materialdried with anhydrous sodium sulfate
filtrationfiltered
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-cc3f89ebc86a4743a1323c4afc3e874e
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07825151B2

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