Bromine → 2-Amino-3-bromo-5-methylbenzoic acid

HRID 1169977노트

반응식

HRID 1169977 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br>C(O)(=O)C>[NH2:1][C:2]1[C:10]([Br:12])=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 24408BromineHCID 762552-Amino-5-methylbenzoic acid

생성물 1

HCID 27744002-Amino-3-bromo-5-methylbenzoic acid수율 85.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2-amino-5-methylbenzoic acid (25.0 g, 170 mmol) in acetic acid (250 ml) was added bromine (10 ml, 195 mmol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was filtered and the solid material was washed with water and cyclohexane and dried to give the title compound (33.4 g).

후처리

  1. filtrationThe mixture was filtered
  2. washthe solid material was washed with water and cyclohexane
  3. customdried

출처 및 근거

ORD 기록
ord-5679cf46e3e942f5892e452b3773d499
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825149B2

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