Water → 1-(2-(1H-Imidazol-1-YL)-6-methylpyrimidin-4-YL)ethanone
반응식
CON(C)[C:4]([C:6]1[CH:11]=[C:10]([CH3:12])[N:9]=[C:8]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)[N:7]=1)=[O:5].[CH3:19][Mg+].[Br-].O>C1COCC1>[N:13]1([C:8]2[N:7]=[C:6]([C:4](=[O:5])[CH3:19])[CH:11]=[C:10]([CH3:12])[N:9]=2)[CH:17]=[CH:16][N:15]=[CH:14]1참가 물질
5
실험 절차
To a solution of 2-imidazol-1-yl-6-methyl-pyrimidine-4-carboxylic acid methoxy-methyl-amide (162 mg, 0.800 mmol) in THF (10 mL) at 0° C. was added MeMgBr (0.8 mL, 3M in Et2O, 2.40 mmol). The solution was warmed to rt and stirred for 20 min. Water was added and the mixture was extracted with ethyl acetate, washed with brine and dried over Na2SO4. Evaporation of the solvent gave 143 mg (88%) of 1-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-ethanone as a yellow solid. [M+H]+ 203.17.
후처리
- extractionthe mixture was extracted with ethyl acetate
- washwashed with brine
- dry with materialdried over Na2SO4
- customEvaporation of the solvent
출처 및 근거
- ORD 기록
- ord-06711d698ea64476962752ae4ca9ecae
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07825256B2
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