2-[2-(1H-Imidazol-1-yl)-6-methylpyrimidin-4-yl]-2-methylpropanoic acid → HCID 11718753, 화합물
반응식
[N:1]1([C:6]2[N:11]=[C:10]([C:12]([CH3:17])([CH3:16])[C:13]([OH:15])=O)[CH:9]=[C:8]([CH3:18])[N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(OC(=O)[N:25]([CH2:36][CH2:37][NH2:38])[CH2:26][C:27]1[CH:35]=[CH:34][C:30]2[O:31][CH2:32][O:33][C:29]=2[CH:28]=1)(C)(C)C>>[O:31]1[C:30]2[CH:34]=[CH:35][C:27]([CH2:26][NH:25][CH2:36][CH2:37][NH:38][C:13](=[O:15])[C:12]([C:10]3[CH:9]=[C:8]([CH3:18])[N:7]=[C:6]([N:1]4[CH:5]=[CH:4][N:3]=[CH:2]4)[N:11]=3)([CH3:17])[CH3:16])=[CH:28][C:29]=2[O:33][CH2:32]1참가 물질
3
실험 절차
N-{2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-ethyl}-2-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-isobutyramide was prepared following the procedures described in the preparation of Example 56 using 2-(2-imidazol-1-yl-6-methyl-pyrimidin-4-yl)-2-methyl-propionic acid and (2-amino-ethyl)-benzo[1,3]dioxol-5-ylmethyl-carbamic acid tert-butyl ester. [M+H]+ 423.26; 1H NMR (400 MHz, CD3OD) δ 8.70 (s, 1H), 8.00 (s, 1H), 7.35 (s, 1H), 7.14 (s, 1H), 6.94-6.80 (m, 3H), 5.98 (s, 2H), 4.10 (s, 2H), 3.53 (t, 2H), 3.13 (t, 2H), 2.58 (s, 3H), 1.63 (s, 6H).
출처 및 근거
- ORD 기록
- ord-f7eef22f89f749099d8f1350e5166d65
- 출처 데이터셋
- uspto-grants-2010_11
- DOI