반응식
[CH2:1]([C:8]1[N:12]([CH:13]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:14]([NH:16][CH:17]2C[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[C:11]2[CH:29]=[C:30]([Cl:34])[C:31]([F:33])=[CH:32][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([CH:41]=[O:42])CCCCC1.[Cl:43]C1C=C(C=CC=1)C=O.ClC1C=C(CC(O)=O)C=CC=1.COC(C(O)=O)C1C=CC=CC=1.C1([N+]#[C-])CCCCC1.C1([N+]#[C-])CCCC1>>[Cl:34][C:30]1[C:31]([F:33])=[CH:32][C:10]2[N:9]=[C:8]([CH:1]([O:42][CH3:41])[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[N:12]([CH:13]([C:23]3[CH:24]=[CH:25][CH:26]=[C:27]([Cl:43])[CH:28]=3)[C:14]([NH:16][CH:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:15])[C:11]=2[CH:29]=1참가 물질
8
반응물 7
생성물 1
실험 절차
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with 3-chlorobenzaldehyde ([CAS RN 587-04-2]), (3-chloro-phenyl)-acetic acid with DL-α-methoxyphenylacetic acid ([CAS RN 7021-09-2]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 526.2 [M+H]+.
출처 및 근거
- ORD 기록
- ord-2b0d2eaf6c4e4d158c8cef5a29fa8bc7
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07825258B2
연결된 노트
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