3-Chlorophenylacetic acid → HCID 67371707, 화합물

HRID 1170714

반응식

HRID 1170714 반응식
[CH2:1]([C:8]1[N:12]([CH:13]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C:14]([NH:16][CH:17]2C[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[C:11]2[CH:29]=[C:30]([Cl:34])[C:31]([F:33])=[CH:32][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([CH:41]=[O:42])CCCCC1.[CH3:43][O:44]C1C=CC(C=O)=CC=1.ClC1C=C(CC(O)=O)C=CC=1.C1(C(OC)C(O)=O)CCCCC1.C1([N+]#[C-])CCCCC1.C1([N+]#[C-])CCCC1>>[Cl:34][C:30]1[C:31]([F:33])=[CH:32][C:10]2[N:9]=[C:8]([CH:1]([CH:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)[O:44][CH3:43])[N:12]([CH:13]([C:23]3[CH:24]=[CH:25][C:26]([O:42][CH3:41])=[CH:27][CH:28]=3)[C:14]([NH:16][CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)=[O:15])[C:11]=2[CH:29]=1

참가 물질

8

반응물 7

HCID 158793-Chlorophenylacetic acidHCID 16275CyclohexanecarboxaldehydeHCID 312444-MethoxybenzaldehydeHCID 79129Cyclohexyl isocyanideHCID 2734784Cyclopentyl IsocyanideHCID 215051022-Cyclohexyl-2-methoxyacetic acidHCID 673736232-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide

생성물 1

HCID 67371707HCID 67371707, 화합물

실험 절차

The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with anisaldehyde ([CAS RN 123-11-5]), (3-chloro-phenyl)-acetic acid with DL-cyclohexyl-methoxy-acetic acid ([CAS RN 15540-18-8]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 528.3 [M+H]+.

출처 및 근거

ORD 기록
ord-85c1fa9ac39c43beb9f31f70efcf976b
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825258B2

연결된 노트

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