Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperonal → 2-Benzo[1,3]dioxol-5-yl-2-[6-chloro-2-(cyclohexyl-methoxy-methyl)-5-fluoro-benzoimidazol-1-yl]-N-cyclopentyl-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperonal | HCID 8438 | — |
| 반응물 | 3-Chlorophenylacetic acid | HCID 15879 | — |
| 반응물 | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| 반응물 | Cyclohexyl isocyanide | HCID 79129 | — |
| 반응물 | Cyclopentyl Isocyanide | HCID 2734784 | — |
| 반응물 | 2-Cyclohexyl-2-methoxyacetic acid | HCID 21505102 | — |
| 반응물 | 2-(2-Benzyl-6-chloro-5-fluoro-benzoimidazol-1-yl)-2,N-dicyclohexyl-acetamide | HCID 67373623 | — |
| 생성물 | 2-Benzo[1,3]dioxol-5-yl-2-[6-chloro-2-(cyclohexyl-methoxy-methyl)-5-fluoro-benzoimidazol-1-yl]-N-cyclopentyl-acetamide | HCID 67373916 | — |
반응 단계
The title compound was prepared in analogy to Example 1, replacing (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester with (2-amino-4-chloro-5-fluoro-phenyl)-carbamic acid tert-butyl ester (([CAS RN 579474-50-3]), Example 47), cyclohexanecarbaldehyde with piperonal ([CAS RN 120-57-0]), (3-chloro-phenyl)-acetic acid with DL-cyclohexyl-methoxy-acetic acid ([CAS RN 15540-18-8]) and cyclohexyl isocyanide with cyclopentyl isocyanide ([CAS RN 68498-54-4]). MS (ISP): 542.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07825258B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-3f6a9325fc534bb69c70eb0b1fd32576 |
| 출처 메모 | uspto-grants-2010_11 |