Tert-Butylamine → N-t-Butyl 3-bromobenzamide

HRID 1170763노트

반응식

HRID 1170763 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:6]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 74377Benzoyl chloride, 3-bromo-

생성물 1

HCID 603211N-t-Butyl 3-bromobenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 3-bromo-benzoyl chloride (0.83 g, 3.8 mmol) in DCM (10 mL) was chilled to zero degrees and treated with tert-butylamine (1.2 mL, 11.3 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (0.9 g, 94%).

후처리

  1. customReaction
  2. customto come to room temperature
  3. additionMixture was then poured onto water
  4. washwashed once
  5. washOrganic phase then washed with brine
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to amber oil (0.9 g, 94%)

출처 및 근거

ORD 기록
ord-8f6dd870cf754a6ea8895f95441b8e3e
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825246B2

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