1,3-Bis(aminomethyl)cyclohexane → (3-Aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine

HRID 1171042

반응식

HRID 1171042 반응식
Cl[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH:12]=[CH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)[NH:3]1.[NH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH:28]([CH2:32][NH2:33])[CH2:27]1>C(O)C>[NH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH:28]([CH2:32][NH:33][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH:12]=[CH:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=[CH:16][CH:15]=3)[N:3]=2)[CH2:27]1

참가 물질

4

반응물 2

HCID 174061,3-Bis(aminomethyl)cyclohexaneHCID 1784783434-Chloro-2-(2-naphthalen-1-yl-vinyl)-3,4-dihydro-quinazoline

생성물 1

HCID 68681390(3-Aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Chloro-2-(2-naphthalen-1-yl-vinyl)-3,4-dihydro-quinazoline (0.08 mmol), C-(3-aminomethyl-cyclohexyl)-methylamine (0.24 mmol) and 2 ml ethyl alcohol are placed in an 8 ml glass vial sealed with a teflon-lined screw cap. The mixture is heated at 80° for 3 hrs. After cooling to rt, the ethyl alcohol is removed. Ethyl acetate (3 ml) and water (3 ml) are added to the vial. After agitation, the water was removed. The procedure is repeated with water and aq. NaCl (sat.). Purification with silica gel afforded (3-aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine;

후처리

  1. customcap
  2. temperatureThe mixture is heated at 80° for 3 hrs
  3. customthe ethyl alcohol is removed
  4. additionEthyl acetate (3 ml) and water (3 ml) are added to the vial
  5. customAfter agitation, the water was removed
  6. customPurification with silica gel

출처 및 근거

ORD 기록
ord-3e196e30367a4ea7a3fb9a80d5c0c842
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07829566B2

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