Acrylonitrile → 4-Cyano-2-diaminomethylene-butyric acid ethyl ester

HRID 1171184노트

반응식

HRID 1171184 반응식
Cl.[CH2:2]([O:4][C:5](=[O:10])[CH:6]=[C:7]([NH2:9])[NH2:8])[CH3:3].C(N(CC)CC)C.[C:18](#[N:21])[CH:19]=[CH2:20]>O1CCCC1>[CH2:2]([O:4][C:5](=[O:10])[C:6]([CH2:20][CH2:19][C:18]#[N:21])=[C:7]([NH2:9])[NH2:8])[CH3:3]

참가 물질

5

반응물 3

HCID 7855AcrylonitrileHCID 8471TriethylamineHCID 124946853,3-Diamino-acrylic acid ethyl ester hydrochloride

생성물 1

HCID 124949064-Cyano-2-diaminomethylene-butyric acid ethyl ester수율 25%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The resulting 3,3-diamino-acrylic acid ethyl ester hydrochloride (2.2 g, 13.2 mmol) was suspended in tetrahydrofuran (40 mL) followed by the addition of triethylamine (2 mL, 14.3 mmol) and acrylonitrile (1.2 mL, 19.3 mmol) and refluxing while heating for 6 hours. Following completion of the reaction, the resulting triethylamine hydrochloride was filtered out and the filtrate was concentrated to obtain the title compound (0.6 g, 3.3 mmol, 25%).

후처리

  1. temperaturerefluxing
  2. temperaturewhile heating for 6 hours
  3. customcompletion of the reaction
  4. filtrationthe resulting triethylamine hydrochloride was filtered out
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-2ca895c509b94913a9a403f59a44bd3b
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07829585B2

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