Ethanol → HCID 86245030, 화합물
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([O:14][CH2:20][CH3:21])=[O:13]참가 물질
4
실험 절차
A mixture composed of 5.21 g (20 mmol) of (2-bromo-5-nitrophenyl)acetic acid (Zhumal Organicheskoi Khimii (1974) 10, 92-5), 80 ml of absolute ethanol and 0.1 ml of concentrated sulfuric acid is refluxed for 6 hours. After cooling, the reaction medium is concentrated under vacuum and taken up in ether. This organic phase is washed with saturated NaHCO3 solution and then with water, after which it is dried over Na2SO4. After concentrating under vacuum, 5.54 g of a beige solid are obtained.
후처리
- temperatureis refluxed for 6 hours
- temperatureAfter cooling
- concentrationthe reaction medium is concentrated under vacuum
- washThis organic phase is washed with saturated NaHCO3 solution
- dry with materialwith water, after which it is dried over Na2SO4
- concentrationAfter concentrating under vacuum, 5.54 g of a beige solid
- customare obtained
출처 및 근거
- ORD 기록
- ord-a0acd240f22f4725a8b2ef91f5abc032
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07829721B2
반응 노트
불러오는 중…