Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → Sertaconazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (+-)-alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol | HCID 32238 | — |
| 반응물 | Sertaconazole Nitrate | HCID 200103 | — |
| 반응물 | 3-(Bromomethyl)-7-chlorobenzo[b]thiophene | HCID 11379988 | — |
| 촉매 | Tetrabutylammonium Chloride | HCID 70681 | — |
| 용매 | Toluene water | HCID 22272177 | — |
| 생성물 | Sertaconazole | HCID 65863 | — |
반응 단계
The specification CN 1358719 (CAPLUS 2003:711267) discloses the synthesis of sertaconazole mononitrate (I) by etherifying 3-bromomethyl-7-chlorobenzo[b]thiophene (III) with 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol (II) at a molar ratio of 1:1 in toluene-water (3:1, v/v) in the presence of sodium hydroxide and 50% tetrabutylammonium chloride (IV, Z═Cl) solution at 80° C. for 4 hours, extracting with ethyl ether to obtain free base of sertaconazole, salifying with nitric acid and recrystallizing in 95% ethanol. The resulting content in sertaconazole mononitrate of the thus prepared product is >98.5%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07829726B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-7220f8852a7f442c812ae69241ac006e |
| 출처 메모 | uspto-grants-2010_11 |