Methanol → s-Glycerylcysteine

HRID 1172011노트

반응식

HRID 1172011 반응식
C(N(CC)CC)C.Cl.[NH2:9][C@H:10]([C:13]([OH:15])=[O:14])[CH2:11][SH:12].Br[CH2:17][CH:18]([OH:21])[CH2:19][OH:20].CO>O.CC(C)=O>[OH:21][CH:18]([CH2:19][OH:20])[CH2:17][S:12][CH2:11][C@@H:10]([C:13]([OH:15])=[O:14])[NH2:9]

참가 물질

7

반응물 4

HCID 887MethanolHCID 8471TriethylamineHCID 208273-Bromo-1,2-propanediolHCID 60960Cysteine Hydrochloride

생성물 1

HCID 15060047s-Glycerylcysteine

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매2회

실험 절차

Triethylamine (6 g, 8.2 ml, 58 mmoles) was added to L-cysteine hydrochloride (3 g, 19 mmole) and 3-bromo-propan-1,2-diol (4.2 g, 2.36 ml, 27 mmole) in water and the homogeneous solution kept at room temperature for 3 days. The solution was reduced in vacuo at 40° C. to a white residue which was boiled with methanol (100 ml), centrifuged and the residue dissolved in water (5 ml). This aqueous solution was added to acetone (300 ml) and the precipitate isolated by centrifugation. The precipitate was purified by several precipitations from water with acetone to give S-(2,3-dihydroxypropyl)cysteine as a white amorphous powder (2.4 g, 12.3 mmol, 64.7%).

후처리

  1. customwas reduced in vacuo at 40° C. to a white residue which
  2. customthe precipitate isolated by centrifugation
  3. customThe precipitate was purified by several precipitations from water with acetone

출처 및 근거

ORD 기록
ord-5620671e92424de6be402148bdb387a6
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833532B2

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