Thionyl Chloride → 5-Chloromethyl-4-methoxy-6-trifluoromethylpyrimidine

반응식

S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[C:12]([CH2:13]O)=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[CH:9][N:8]=1>>[Cl:3][CH2:13][C:12]1[C:7]([O:6][CH3:5])=[N:8][CH:9]=[N:10][C:11]=1[C:15]([F:18])([F:17])[F:16]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 17862874(4-Methoxy-6-trifluoromethylpyrimidin-5-yl)-methanol

생성물 1

HCID 178629155-Chloromethyl-4-methoxy-6-trifluoromethylpyrimidine수율 98.3%

실험 절차

1.19 g (10.1 mmoles) of thionyl chloride was added, at room temperature, to a solution of 0.42 g (2.02 mmoles) of (4-methoxy-6-trifluoromethylpyrimidin-5-yl)-methanol. The mixture was stirred for 3 hours to give rise to a reaction. After confirmation of the completion of the reaction, the reaction mixture was subjected to vacuum distillation to remove the solvent contained therein, to obtain 0.45 g (yield: quantitative) of 5-chloromethyl-4-methoxy-6-trifluoromethylpyrimidine.

후처리

customto give rise
customto a reaction
customAfter confirmation of the completion of the reaction
distillationthe reaction mixture was subjected to vacuum distillation
customto remove the solvent

출처 및 근거

ORD 기록: ord-0fec67e81af949879ab8a5d41ec983cc
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07833939B2

반응 노트

불러오는 중…