Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 11722생성일: 2026년 10월 24일
7-Chloro-benzo[1,4]dioxin-2-one → 2-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone
https://huagongshe.com/ko/reaction/11722
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 7-Chloro-benzo[1,4]dioxin-2-one | HCID 3255318 | — |
| 반응물 | (r)-1-(4-Fluorobenzyl)-3-methylpiperazine | HCID 11600914 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone | HCID 69655856 | 52.9% |
반응 단계
To a solution of 7-chloro-benzo[1,4]dioxin-2-one (0.845 g, 4.81 mmol) in toluene (25 mL) was added (3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine (1.003 g, 4.81 mmol). The resulting mixture was heated to 95° C. overnight. The reaction was cooled to ambient temperature, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (˜1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07098212B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-6326dfff423e40298d12cdfe41a6ac19 |
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| 출처 메모 | uspto-grants-2006_08 |
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