Aluminium lithium hydride → 3-(Aminomethyl)-N-(2,4-dimethoxybenzyl)pyridin-2-amine

HRID 1172294

반응식

HRID 1172294 반응식
[CH3:1][O:2][C:3]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:4]=1[CH2:5][NH:6][C:7]1[C:12]([C:13]#[N:14])=[CH:11][CH:10]=[CH:9][N:8]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][O:2][C:3]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:4]=1[CH2:5][NH:6][C:7]1[C:12]([CH2:13][NH2:14])=[CH:11][CH:10]=[CH:9][N:8]=1

참가 물질

3

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 222931752-(2,4-Dimethoxybenzylamino)nicotinonitrile

생성물 1

HCID 222931603-(Aminomethyl)-N-(2,4-dimethoxybenzyl)pyridin-2-amine

실험 절차

A solution of 2-(2,4-Dimethoxybenzylamino)pyridine-3-carbonitrile (0.55 g, 2.04 mmol) and LiAlH4 (2.2 ml of 1N, 4.4 mmol) was stirred at RT until the reaction was judged complete by LCMS. The reaction was quenched with sat. aq. Na2CO3 and the layers were separated. The organic layer was dried (Na2SO4) and the solvents removed under reduced pressure giving the desired product which was used without further purification. LC/MS (10% to 99%): M/Z (M+H)+ (obs)=274; tR=0.28.

후처리

  1. customThe reaction was quenched with sat. aq. Na2CO3
  2. customthe layers were separated
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. customthe solvents removed under reduced pressure

출처 및 근거

ORD 기록
ord-dff5d436576f492d92676e077592d302
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834000B2

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