TBAF tetrahydrofuran → (6-(Thiazol-2-ylamino)pyridin-2-yl)methanol

HRID 1172412노트

반응식

HRID 1172412 반응식
[Si]([O:8][CH2:9][C:10]1[N:15]=[C:14]([NH:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)[CH:13]=[CH:12][CH:11]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.O1CCCC1>O1CCCC1.C(OCC)(=O)C>[S:18]1[CH:19]=[CH:20][N:21]=[C:17]1[NH:16][C:14]1[N:15]=[C:10]([CH2:9][OH:8])[CH:11]=[CH:12][CH:13]=1

참가 물질

5

반응물 2

HCID 11078149TBAF tetrahydrofuranHCID 57562580HCID 57562580, 화합물

생성물 1

HCID 57562655(6-(Thiazol-2-ylamino)pyridin-2-yl)methanol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

6.48 g of 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine was dissolved in 100 ml of tetrahydrofuran. Under cooling with ice, a tetrabutylammonium fluoride-tetrahydrofuran solution (1.0 M, 20.2 ml) was added followed by stirring at room temperature for 1 hour. The reaction solution was diluted with ethyl acetate and then washed with phosphate buffer (pH 6.8). The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated to give the title compound.

후처리

  1. temperatureUnder cooling with ice
  2. washwashed with phosphate buffer (pH 6.8)
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-7581c32cd57e40a8bfdb717316fe3613
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834018B2

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