4-Bromobenzoic acid → 4-Bromo-3-(chlorosulfonyl)benzoic acid

반응식

[Cl:1][S:2]([OH:5])(=O)=[O:3].[Br:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1>>[Br:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[S:2]([Cl:1])(=[O:5])=[O:3]

참가 물질

반응물 2

HCID 114644-Bromobenzoic acid

HCID 24638Chlorosulfonic acid

생성물 1

HCID 37373734-Bromo-3-(chlorosulfonyl)benzoic acid

반응 조건

온도: 110 °C

실험 절차

Chlorosulfonic acid (70 mL, 1.05 mol) cooled to 0° C. was added dropwise with stirring to 4-bromo-benzoic acid (50 g, 0.29 mol). The reaction mixture was heated at 110° C. for 10 h, cooled to room temperature and poured onto crushed ice slowly with stirring. The title compound obtained was filtered, washed with water and dried. Yield: 51 g, (84%); mp: 198-199° C.; MS: m/e (EI+) 299 (M+).

후처리

additionwas added dropwise
temperaturecooled to room temperature
additionpoured
customonto crushed ice slowly

출처 및 근거

ORD 기록: ord-c21e3b7638a140fda12598cc8ceb3bd3
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07834001B2

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