Sodium Carbonate → cis-(2-Pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol

HRID 1172560노트

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HRID 1172560 반응식
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][C@H:8]([CH2:11][OH:12])[CH2:9][CH2:10][C@@H:2]12.Cl[C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1.C([O-])([O-])=O.[Na+].[Na+]>O>[N:15]1[CH:16]=[CH:17][CH:18]=[N:19][C:14]=1[N:6]1[CH2:5][CH2:4][N:3]2[CH2:7][C@H:8]([CH2:11][OH:12])[CH2:9][CH2:10][C@H:2]2[CH2:1]1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 744042-ChloropyrimidineHCID 10035034((7R,9AS)-Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

생성물 1

HCID 14995231cis-(2-Pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol

시약·촉매·용매 1

HCID 962Water용매

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온도
95 °C

실험 절차

Cis-(octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol (1 eq), 2-chloro-pyrimidine (1 eq.), and Na2CO3 (1 eq.) were dissolved in water. The mixture was stirred at around 95° C. for overnight. The solution was cooled to room temperature and extracted with methylene chloride. The combined organic layers was washed with brine, dried over Na2SO4, filtered and concentrated to give cis-(2-pyrimidin-2-yl-octahydro-pyrido[1,2-a]pyrazin-7-yl)-methanol as a white solid. This material was used in the next step without further purification.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. extractionextracted with methylene chloride
  3. washThe combined organic layers was washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3f01ef0aa3e34a8da279058e905b7167
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834014B2

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