Borane → 3-(2-Fluoro-3-methylphenyl)propan-1-ol

HRID 1172598노트

반응식

HRID 1172598 반응식
[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11](O)=[O:12].B>C1COCC1>[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][OH:12]

참가 물질

4

반응물 2

HCID 6331BoraneHCID 57659614955403-63-1

생성물 1

HCID 576596103-(2-Fluoro-3-methylphenyl)propan-1-ol수율 82.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

According to procedures described above, 3-(2-fluoro-3-methyl-phenyl)-propionic acid (2.39 g, 13.12 mmol) was reduced by borane in THF to give 1.82 g (82.5%) of 3-(2-fluoro-3-methyl-phenyl)-propan-1-ol. LC-MS: tR=0.86 min; [M+H]+=no ionization.

출처 및 근거

ORD 기록
ord-643e7bf0ed9b4038a6591460dbe114d9
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834028B2

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