Methanesulfonyl chloride → HCID 58958827, 화합물

HRID 1172604노트

반응식

HRID 1172604 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH2:26][CH2:27][OH:28])=[CH:22][CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[C:9]2[CH2:14][CH2:13][CH2:12][N:10]2[N:11]=1.[CH3:29][S:30](Cl)(=[O:32])=[O:31]>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH2:26][CH2:27][O:28][S:30]([CH3:29])(=[O:32])=[O:31])=[CH:22][CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[C:9]2[CH2:14][CH2:13][CH2:12][N:10]2[N:11]=1

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 17980603700874-74-4

생성물 1

HCID 58958827HCID 58958827, 화합물수율 100%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Stir a solution of 2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolin-7-yloxy]-ethanol (293 mg, 0.78 mmol) and methane sulfonyl chloride (68 μL, 0.81 ml) in dried pyridine (5 mL) for 2 hours. Remove the pyridine in vacuo and recover the residue with chloroform. Wash the organic layer with saturated sodium bicarbonate and dry over sodium sulfate to give the desired subtitled intermediate as a white foam (425 mg, 100%). MS ES+ m/e 451.1 (M+1).

후처리

  1. customRemove the pyridine in vacuo
  2. customrecover the residue with chloroform
  3. washWash the organic layer with saturated sodium bicarbonate
  4. dry with materialdry over sodium sulfate

출처 및 근거

ORD 기록
ord-81ca455eb772452dae30e82b0c30d09d
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834029B2

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