4-Fluoro-2-vinyl-benzonitrile → 2-Ethyl-4-fluorobenzonitrile

HRID 1172681노트

반응식

HRID 1172681 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH:10]=[CH2:11])[CH:3]=1>CO.[Pd]>[CH2:10]([C:4]1[CH:3]=[C:2]([F:1])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])[CH3:11]

참가 물질

4

반응물 1

HCID 595563374-Fluoro-2-vinyl-benzonitrile

생성물 1

HCID 234392762-Ethyl-4-fluorobenzonitrile수율 77.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

800 mg 4-Fluoro-2-vinyl-benzonitrile were dissolved in 5 ml methanol. 80 mg palladium (10% on charcoal) were added and the reaction was stirred under a hydrogen atmosphere for one hour. The catalyst was filtered off trough a pad of celite. The filtrate was evaporated to obtain 625 mg 2-Ethyl-4-fluoro-benzonitrile.

후처리

  1. filtrationThe catalyst was filtered off trough a pad of celite
  2. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-2b38a61d2c924003b8d6f911058d88ae
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834030B2

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