Thionyl Chloride → 4-Fluoro-N-methyl-benzimidoyl chloride

반응식

[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][CH3:9])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([Cl:14])=[N:8][CH3:9])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 40742474-fluoro-N-methylbenzamide

생성물 1

HCID 866151304-Fluoro-N-methyl-benzimidoyl chloride

실험 절차

A suspension of 4-fluoro-N-methyl-benzamide (CAS: 701-49-5, 0.106 g, 0.69 mmol) in thionyl chloride (202 mL, 2.78 mmol) was refluxed for 1 h 30 min. The solvent was removed under reduced pressure, then toluene was added and the solvent was evaporated under reduced pressure to afford a yellow oil used immediately for the next step.

후처리

temperaturewas refluxed for 1 h 30 min
customThe solvent was removed under reduced pressure
additiontoluene was added
customthe solvent was evaporated under reduced pressure
customto afford a yellow oil

출처 및 근거

ORD 기록: ord-cb76aba1c7d0460b9ef34c45e6f90953
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07834035B2

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