Water → 2-(4-chlorophenoxy)benzaldehyde

HRID 1172806노트

반응식

HRID 1172806 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.F[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1.O>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:12]2[CH:11]=[CH:10][CH:17]=[CH:16][C:13]=2[CH:14]=[O:15])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 46844-ChlorophenolHCID 680234-Fluorobenzaldehyde

생성물 1

HCID 27676752-(4-chlorophenoxy)benzaldehyde

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A heterogeneous mixture of 4-chlorophenol (14.1 g, 0.11 mmol), 4-fluorobenzaldehyde 12.4 g, 0.1 mmol) and CS2CO3 (65.0 g, 0.20 mmol) in DMF (400 mL) was stirred at 90° C. for 6 h. The reaction mixture was poured into water (1.2 L) and extracted with ethyl acetate (2×200 mL). The organic phase was washed with water (2×100 mL), dried over magnesium sulfate and concentrated to give essentially pure 4-chlorophenoxybenzaldehyde, which was used directly in the next step.

후처리

  1. extractionextracted with ethyl acetate (2×200 mL)
  2. washThe organic phase was washed with water (2×100 mL)
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7254549d83c34e3da66611934fe9aa39
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834036B2

반응 노트

불러오는 중…