1-[4-(4-Chlorophenoxy)-2-propylphenyl]-2-(4-methoxyphenoxy)ethanone → 3-[4-(4-Chlorophenoxy)-2-propylphenyl]-5-methoxy-1-benzofuran

HRID 1172814노트

반응식

HRID 1172814 반응식
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=O)[CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)=[C:9]([CH2:25][CH2:26][CH3:27])[CH:8]=2)=[CH:4][CH:3]=1>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[C:17]4[CH:18]=[C:19]([O:22][CH3:23])[CH:20]=[CH:21][C:16]=4[O:15][CH:14]=3)=[C:9]([CH2:25][CH2:26][CH3:27])[CH:8]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 686927541-[4-(4-Chlorophenoxy)-2-propylphenyl]-2-(4-methoxyphenoxy)ethanone

생성물 1

HCID 686903343-[4-(4-Chlorophenoxy)-2-propylphenyl]-5-methoxy-1-benzofuran

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
140 °C

실험 절차

A mixture of the product from Step 9 (0.46 g, 1.1 mmol) and Amberlyst-15 (0.50 g) in xylene (10 mL) was heated at 140° C. for 2 h. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by chromatography on silica gel to give the title product.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-2fa12822554b49e6951c8646e4de0d96
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834036B2

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