참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Diphenylphosphine | HCID 70017 | — |
| 반응물 | Trioctylsilane, 95% | HCID 87780 | — |
| 반응물 | 4-(4-Chlorophenoxy)-2-propylphenyl trifluoromethanesulfonate | HCID 57420139 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-(4-Chlorophenoxy)-2-propylbenzaldehyde | HCID 57420143 | — |
반응 단계
A mixture of the triflate from Step 6 of Example 1 (3.98 g, 10 mmol), trioctylsilane (6.7 mL, 15 mmol), triethyl amine (7.0 mL, 25 mmol), palladium acetate (0.22 g, 0.5 mmol) and diphenylphosphine (0.21 g, 0.5 mmol) in DMF (60 mL) was stirred at 80° C. under an atmosphere of carbon monoxide (50 psi) for 5 h. The reaction was then diluted with ethyl acetate and water. The organic layer was washed with water and concentrated. The residue was purified by chromatography on silica gel to give the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07834036B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_11 |
|---|
| ORD ID | ord-3b6927da955b4e40becf93811e4e50c6 |
|---|
| 출처 메모 | uspto-grants-2010_11 |
|---|
