Trifluoroacetic acid → 5-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

HRID 1172848노트

반응식

HRID 1172848 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]2[S:9][C:10]([C:12]([OH:14])=[O:13])=[CH:11][C:7]=2[CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59556407Benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester

생성물 1

HCID 595564095-(Methoxycarbonyl)benzo[b]thiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of benzo[b]thiophene-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester (3.018 g, 10.32 mmol) and TFA (20 mL) in CH2Cl2 (50 mL) was allowed to stir at rt for four days. The reaction mixture was concentrated and dried under high vacuum to give benzo[b]thiophene-2,5-dicarboxylic acid 5-methyl ester as a pale solid. MS (EI): cal'd 237.0 (MH+), exp 237.1 (MH+).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-3f805adbaac54592967313b717127e28
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834034B2

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