Chlorosulfonic acid → 4-(2-Sulfamoylethyl)benzenesulfonyl chloride

HRID 1173100노트

반응식

HRID 1173100 반응식
[C:1]1([CH2:7][CH2:8][S:9]([NH2:12])(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[S:9]([CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][C:4]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:5][CH:6]=1)(=[O:10])(=[O:11])[NH2:12]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 204808Benzeneethanesulfonamide

생성물 1

HCID 223592554-(2-Sulfamoylethyl)benzenesulfonyl chloride수율 77.2%

실험 절차

1.3 g (7.3 mmol) of 2-phenylethanesulfonamide was added to 2.4 g (36.5 mmol) of chlorosulfonic acid under ice-cooling over 20 minutes, followed by stirring at room temperature for further 90 minutes. The reaction mixture solution was poured into ice-water, and then extracted with ethyl acetate. The extract was successively washed with an aqueous saturated sodium bicarbonate and brine, and dried over magnesium sulfate. The solvent was evaporated, to give 1.6 g of the title compound.

후처리

  1. temperaturecooling over 20 minutes
  2. extractionextracted with ethyl acetate
  3. washThe extract was successively washed with an aqueous saturated sodium bicarbonate and brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-9ec12645fce04357a1abc45e77bdeb35
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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