Ammonia → 1H-pyrrolo[2,3-c]pyridin-7-amine

HRID 1173108

반응식

HRID 1173108 반응식
N.Br[C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12.BrC1C([N+]([O-])=O)=CC=C[N:14]=1>[Cu]>[NH2:14][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 5550542-Bromo-3-nitropyridineHCID 196964567-Bromo-6-azaindole

생성물 1

HCID 190801861H-pyrrolo[2,3-c]pyridin-7-amine

시약·촉매·용매 1

HCID 23978Copper촉매

반응 조건

온도
120 °C

실험 절차

To 84 ml of aqueous concentrated ammonia were added 600 mg (3.05 mmol) of 7-bromo-1H-pyrrolo[2,3-c]pyridine synthesized from 2-bromo-3-nitropyridine in the same manner as in Production Example 1a, 194 mg of a copper powder and 603 mg of cuprous chloride. The mixture was heated in a sealed tube at 120° C. for 15 hours and then treated, to give 170 mg of 7-amino-1H-pyrrolo[2,3-c]pyridine. The resulting product was reacted and treated in the same manner as in Examples 1a and 2a, to give 57 mg of the title compound.

후처리

  1. additiontreated

출처 및 근거

ORD 기록
ord-1984b068d707462f827e7c0a08a19cc2
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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