Ammonia → 1,6-Naphthyridin-2-amine

HRID 1173123노트

반응식

HRID 1173123 반응식
Cl[C:2]1[C:11]2[C:6](=C[C:8]([NH:12]S(C3C=CC(C)=CC=3)(=O)=O)=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH3:23]>>[NH2:23][C:8]1[CH:9]=[CH:10][C:11]2[C:6](=[CH:5][CH:4]=[N:3][CH:2]=2)[N:12]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 22674092HCID 22674092, 화합물

생성물 1

HCID 5893531,6-Naphthyridin-2-amine수율 89.73%

실험 절차

2-Chloro-1,6-naphthyridine (0.628 g, Production Example 22b) and an aqueous ammonia (40 ml) were heated at 130° C. for 11 hours in a sealed tube. After cooling, the mixture was extracted with ethyl acetate, and the extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by silica gel column, to give the title compound (0.497 g, 89.73%) as pale yellow crystals.

후처리

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washthe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated
  6. customthe residue was purified by silica gel column

출처 및 근거

ORD 기록
ord-b492d7e909e84a3b8aeb98ec74f19799
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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