Water → N-(3-Nitrophenethyl)acetamide

HRID 1173125노트

반응식

HRID 1173125 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][CH2:8][NH2:9])([O-:3])=[O:2].[C:13](Cl)(=[O:15])[CH3:14].O>N1C=CC=CC=1>[C:13]([NH:9][CH2:8][CH2:7][C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:15])[CH3:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 129500662-(3-Nitrophenyl)ethan-1-amine

생성물 1

HCID 22674066N-(3-Nitrophenethyl)acetamide수율 91%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3-Nitrophenethylamine (5.559 g, Production Example 25b) was dissolved in pyridine (33 ml), and acetyl chloride (2.5 ml) was added dropwise thereinto under ice-cooling. After stirring at room temperature for 0.5 hr, the mixture was ice-cooled again. Water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (6.323 g, 91%) as a yellow oil.

후처리

  1. temperatureunder ice-cooling
  2. temperaturecooled again
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-7260cf56fccf496ba7bdd8d0ba480c03
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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