4-Iodobenzenesulfonyl chloride → HCID 22674075, 화합물

HRID 1173143노트

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HRID 1173143 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([O:12][CH3:13])=[N:7][CH:6]=[CH:5]2.I[C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1.C([Sn](CCCC)(CCCC)[C:30]1[S:31][CH:32]=[CH:33][N:34]=1)CCC>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:13][O:12][C:8]1[C:9]2[C:4](=[CH:3][C:2]([NH:1][S:21]([C:18]3[CH:19]=[CH:20][C:15]([C:30]4[S:31][CH:32]=[CH:33][N:34]=4)=[CH:16][CH:17]=3)(=[O:23])=[O:22])=[CH:11][CH:10]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

6

반응물 3

HCID 73994-Iodobenzenesulfonyl chlorideHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 226740451-Methoxyisoquinolin-6-amine

생성물 1

HCID 22674075HCID 22674075, 화합물

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 1140Toluene용매

실험 절차

The compound (40 mg) obtained using 6-amino-1-methoxyisoquinoline (Production Example 43b) and 4-iodobenzenesulfonyl chloride in the same method as in Synthetic Example 1b, 2-tri-n-butylstannylthiazole (136 mg) and tetrakis(triphenylphosphine)palladium (0) (11 mg) were heated under reflux for one hour in toluene in a nitrogen atmosphere. After evaporating the solvent, the residue was purified by silica gel column. The resulting crystals were recrystallized from methanol, to give the title compound (20 mg).

후처리

  1. temperaturewere heated
  2. customAfter evaporating the solvent
  3. customthe residue was purified by silica gel column
  4. customThe resulting crystals were recrystallized from methanol

출처 및 근거

ORD 기록
ord-7760b20f743043ccb1e5c3dc8c6ec991
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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