N-{6-[(Phenylmethyl)oxy]-3-pyridinyl}acetamide → HCID 178474274, 화합물
반응식
C1(C[O:8][C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=1참가 물질
4
실험 절차
To a solution of N-{6-[(phenylmethyl)oxy]-3-pyridinyl}acetamide (0.210 g, 0.87 mmol) in EtOH (10 mL) at rt was added Pd—C (0.046 g of 10 wt % on activated carbon (dry basis), ca. 50 wt % H2O; ca. 0.022 mmol Pd). The mixture was placed under an atmosphere of H2 and stirred for 4.5 h. The mixture was filtered through Celite (EtOAc wash) and concentrated in vacuo, affording 0.132 g of the title compound as a colorless solid: MS (ESI) m/z 152 (M+).
후처리
- filtrationThe mixture was filtered through Celite (EtOAc wash)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-6253c988063c46f6b92abd8d073f19a3
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834063B2
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