4-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile → 4-[[2-(4-Pyrimidinyloxy)ethyl](2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173452노트

반응식

HRID 1173452 반응식
[OH:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.[NH:22]1[CH:27]=[CH:26][C:25](=O)[N:24]=[CH:23]1>COCCOC>[N:22]1[CH:27]=[CH:26][C:25]([O:1][CH2:2][CH2:3][N:4]([CH2:17][C:18]([F:19])([F:20])[F:21])[C:5]2[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:15])([F:16])[F:14])[CH:6]=2)=[N:24][CH:23]=1

참가 물질

4

반응물 2

HCID 866237314-[(2-Hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrileHCID 178516534HCID 178516534, 화합물

생성물 1

HCID 116180344-[[2-(4-Pyrimidinyloxy)ethyl](2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

Synthesized as described in Example 27B from 4-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile (Example 15B) and 4(1H)-pyrimidinone, using dry DME as the reaction solvent: MS (ESI) m/z 391 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-f3e1cbfea78f4138a4bf8fd32e475c2c
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834063B2

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