4-(5-Ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrile → Rac-4-[(4r,5r)-5-ethyl-4-hydroxy-3,3-dimethyl-2-oxopyrrolidin-1-yl]-2-methoxybenzonitrile

HRID 1173667노트

반응식

HRID 1173667 반응식
[CH2:1]([CH:3]1[N:7]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([O:16][CH3:17])[CH:9]=2)[C:6](=[O:18])[C:5]([CH3:20])([CH3:19])[C:4]1=[O:21])[CH3:2].C([BH-](C(CC)C)C(CC)C)(CC)C.[Li+].C1COCC1>>[CH2:1]([C@H:3]1[N:7]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([O:16][CH3:17])[CH:9]=2)[C:6](=[O:18])[C:5]([CH3:20])([CH3:19])[C@H:4]1[OH:21])[CH3:2]

참가 물질

3

반응물 2

HCID 595568974-(5-Ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrileHCID 131725857L-SELECTRIDE tetrahydrofuran

생성물 1

HCID 67105799Rac-4-[(4r,5r)-5-ethyl-4-hydroxy-3,3-dimethyl-2-oxopyrrolidin-1-yl]-2-methoxybenzonitrile

실험 절차

Using 4-(5-ethyl-3,3-dimethyl-2,4-dioxopyrrolidin-1-yl)-2-methoxybenzonitrile (120 mg) and lithium tri(sec-butyl)borohydride-THF solution (0.629 mL, 1 mol/L), and in the same manner as in Example 5, the title compound was obtained as a colorless solid (yield: 93 mg, 77%).

출처 및 근거

ORD 기록
ord-4c48f411603d4a6388d7f8654cf1e73e
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834051B2

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